EPH Receptor B4 抗体
Quick Overview for EPH Receptor B4 抗体 (ABIN7113852)
抗原
See all EPH Receptor B4 (EPHB4) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- EPHB4 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: Extracellular,300-539AA
Immunogen: EPH receptor B4
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亚型
- IgG
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应用备注
- WB: 1:500-1:5000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- EPH Receptor B4 (EPHB4)
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别名
- EPHB4
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背景
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Synonyms: Ephrin type-B receptor 4|Hepatoma transmembrane kinase|Tyrosine-protein kinase TYRO11|EPHB4|HTK|MYK1|TYRO11
Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
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分子量
- 110 kDa
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基因ID
- 2050
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UniProt
- P54760
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途径
- RTK signaling
抗原
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