EPH Receptor A8 抗体
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北京 101111
Quick Overview for EPH Receptor A8 抗体 (ABIN7113851)
抗原
See all EPH Receptor A8 (EPHA8) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- EPHA8 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- EPH receptor A8
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亚型
- IgG
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anti-EPH Receptor A8 (EPHA8) (AA 70-150) antibody
EPHA8 适用: 人 ELISA 宿主: 小鼠 Monoclonal 9A12D8 unconjugated
anti-EPH Receptor A8 (EPHA8) (AA 45-249) antibodyEPHA8 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- EPH Receptor A8 (EPHA8)
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别名
- EPHA8
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背景
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Synonyms: Ephrin type-A receptor 8|EPH- and ELK-related kinase|EPH-like kinase 3 (EK3, hEK3)|Tyrosine-protein kinase receptor EEK|EPHA8|EEK|HEK3|KIAA1459
Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth(By similarity).
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分子量
- 120 kDa
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基因ID
- 2046
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UniProt
- P29322
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途径
- RTK signaling
抗原
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