DDIT3 抗体 (AA 1-169)
Quick Overview for DDIT3 抗体 (AA 1-169) (ABIN7113561)
抗原
See all DDIT3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-169
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原理
- DDIT3 antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 1-169aa
Immunogen: DNA-damage-inducible transcript 3
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亚型
- IgG2a
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应用备注
- WB: 1:500-1:5000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))
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别名
- DDIT3
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背景
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Synonyms: DNA damage-inducible transcript 3 protein (DDIT-3)|C/EBP zeta|C/EBP-homologous protein (CHOP)|C/EBP-homologous protein 10 (CHOP-10)|CCAAT/enhancer-binding protein homologous protein|Growth arrest and DNA damage-inducible protein GADD153|DDIT3|CHOP|CHOP10|GADD153
Background: CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins, CHOP is significantly induced by ER stress, deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C/EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma.
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分子量
- 30 kDa
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基因ID
- 1649
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UniProt
- P35638
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途径
- Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis
抗原
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