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DACH1 抗体 (AA 176-521)

This 兔 多克隆 antibody specifically detects DACH1 in WB, ELISA, IHC 和 IP. It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN7113310
发货至: 中国
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北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for DACH1 抗体 (AA 176-521) (ABIN7113310)

抗原

See all DACH1 抗体
DACH1 (Dachshund 1 (DACH1))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This DACH1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • 抗原表位

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    AA 176-521

    原理

    DACH1 antibody

    纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    Immunogen sequence: 176-521 aa

    Immunogen: dachshund homolog 1(Drosophila)

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    DACH1 (Dachshund 1 (DACH1))

    别名

    DACH1

    背景

    Synonyms: Dachshund homolog 1 (Dach1)|DACH1|DACH

    Background: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter(By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain(By similarity).

    分子量

    97-100 kDa

    基因ID

    1602

    UniProt

    Q9UI36

    途径

    Feeding Behaviour
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