DACH1 抗体 (AA 176-521)
Quick Overview for DACH1 抗体 (AA 176-521) (ABIN7113310)
抗原
See all DACH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 176-521
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原理
- DACH1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 176-521 aa
Immunogen: dachshund homolog 1(Drosophila)
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- DACH1 (Dachshund 1 (DACH1))
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别名
- DACH1
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背景
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Synonyms: Dachshund homolog 1 (Dach1)|DACH1|DACH
Background: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter(By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain(By similarity).
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分子量
- 97-100 kDa
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基因ID
- 1602
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UniProt
- Q9UI36
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途径
- Feeding Behaviour
抗原
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