DMP1 抗体
Quick Overview for DMP1 抗体 (ABIN7113139)
抗原
See all DMP1 (DMTF1) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- DMP1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DMP1
Immunogen: Dentin matrix acidic phosphoprotein 1
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
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别名
- DMP1
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背景
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Synonyms: Dentin matrix acidic phosphoprotein 1 (DMP-1, Dentin matrix protein 1)|DMP1
Background: Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
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分子量
- 110 kDa
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UniProt
- Q13316
抗原
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