Exportin 2 抗体
Quick Overview for Exportin 2 抗体 (ABIN7113096)
抗原
See all Exportin 2 (CSE1L) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CSE1L antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- CSE1 chromosome segregation 1-like(yeast)
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))
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别名
- CSE1L
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背景
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Synonyms: Exportin-2 (Exp2)|Cellular apoptosis susceptibility protein|Chromosome segregation 1-like protein|Importin-alpha re-exporter|CSE1L|CAS|XPO2
Background: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates(cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex(NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.
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分子量
- 100-110 kDa
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基因ID
- 1434
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UniProt
- P55060
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途径
- Protein targeting to Nucleus
抗原
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