CHCHD4 抗体
Quick Overview for CHCHD4 抗体 (ABIN7112969)
抗原
See all CHCHD4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- CHCHD4 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- coiled-coil-helix-coiled-coil-helix domain containing 4
-
亚型
- IgG
-
-
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 1-142) antibody
CHCHD4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6C9 unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 1-142) antibodyCHCHD4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (N-Term) antibodyCHCHD4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 1-142) antibodyCHCHD4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (N-Term) antibodyCHCHD4 适用: 人, 小鼠, 大鼠, 豚鼠, 非洲爪蟾, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (N-Term) antibodyCHCHD4 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 101-129), (C-Term) antibodyCHCHD4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB29595 unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 108-137), (C-Term) antibodyCHCHD4 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))
-
别名
- CHCHD4
-
背景
-
Synonyms: Mitochondrial intermembrane space import and assembly protein 40|Coiled-coil-helix-coiled-coil-helix domain-containing protein 4|CHCHD4|MIA40
Background: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1(PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364). Required for the import and folding of small cysteine-containing proteins(small Tim) in the mitochondrial intermembrane space(IMS)(PubMed:16185709, PubMed:19182799, PubMed:21059946). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria(PubMed:16185709, PubMed:19182799, PubMed:21059946). The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS(PubMed:16185709, PubMed:19182799, PubMed:21059946). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system(PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake(PubMed:26387864).
-
分子量
- 22-25 kDa
-
基因ID
- 131474
-
UniProt
- Q8N4Q1
抗原
-
