CHCHD4 抗体 (N-Term)
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- 抗原 See all CHCHD4 抗体
- CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CHCHD4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- CHCHD4 Antibody detects endogenous levels of total CHCHD4.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CHCHD4, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CHCHD4 Primary Antibody
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anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 1-142) antibody
CHCHD4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 6C9 unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 1-142) antibodyCHCHD4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (N-Term) antibodyCHCHD4 适用: 人, 小鼠, 大鼠, 豚鼠, 非洲爪蟾, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 1-142) antibodyCHCHD4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 101-129), (C-Term) antibodyCHCHD4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB29595 unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) (AA 108-137), (C-Term) antibodyCHCHD4 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))
- 别名
- CHCHD4 (CHCHD4 产品)
- 别名
- 2410012P20Rik antibody, 2810014D17Rik antibody, AI838740 antibody, MIA40 antibody, TIMM40 antibody, mia40 antibody, timm40 antibody, chchd4 antibody, chchd4a antibody, fc10g04 antibody, wu:fc10g04 antibody, zgc:100849 antibody, si:dkey-202e22.1 antibody, chchd4b antibody, CaO19.2977 antibody, coiled-coil-helix-coiled-coil-helix domain containing 4 antibody, coiled-coil-helix-coiled-coil-helix domain containing 4 L homeolog antibody, coiled-coil-helix-coiled-coil-helix domain containing 4a antibody, coiled-coil-helix-coiled-coil-helix domain containing 4 S homeolog antibody, Mia40p antibody, Chchd4 antibody, CHCHD4 antibody, chchd4 antibody, chchd4.L antibody, chchd4a antibody, chchd4.S antibody, LOC100361898 antibody, MIA40 antibody
- 背景
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Description: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19 and MICU1 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864).
Gene: CHCHD4
- 分子量
- 22 kDa
- 基因ID
- 131474
- UniProt
- Q8N4Q1
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