CTNNA1 抗体 (AA 200-536)
Quick Overview for CTNNA1 抗体 (AA 200-536) (ABIN7112383)
抗原
See all CTNNA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 200-536
-
原理
- CTNNA1 antibody
-
纯化方法
- Protein A+G purification
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
-
Immunogen sequence: 200-536aa
Immunogen: catenin(cadherin-associated protein), alpha 1, 102kDa
-
亚型
- IgG1
-
-
-
-
应用备注
- WB: 1:500-1:2000, IHC: 1:50-1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
-
别名
- CTNNA1
-
背景
-
Synonyms: Catenin alpha-1|Alpha E-catenin|Cadherin-associated protein|Renal carcinoma antigen NY-REN-13|CTNNA1
Background: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
-
分子量
- 95-100 kDa
-
基因ID
- 1495
-
UniProt
- P35221
-
途径
- Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location
抗原
-