CSNK2A1/CK II alpha 抗体
Quick Overview for CSNK2A1/CK II alpha 抗体 (ABIN7112347)
抗原
See all CSNK2A1/CK II alpha (CSNK2A1) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- casein kinase 2, alpha 1 polypeptide
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亚型
- IgG
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anti-Casein Kinase 2 alpha 1 (CSNK2A1) (AA 1-100) antibody
CSNK2A1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-Casein Kinase 2 alpha 1 (CSNK2A1) (AA 1-391) antibodyCSNK2A1 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 2 alpha 1 (CSNK2A1) (N-Term) antibodyCSNK2A1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 2 alpha 1 (CSNK2A1) (AA 250-284) antibodyCSNK2A1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB48211 unconjugated
anti-Casein Kinase 2 alpha 1 (CSNK2A1) (AA 201-300) antibodyCSNK2A1 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 2 alpha 1 (CSNK2A1) antibodyCSNK2A1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 2 alpha 1 (CSNK2A1) antibodyCSNK2A1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Casein Kinase 2 alpha 1 (CSNK2A1) (pTyr255) antibodyCSNK2A1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Casein Kinase 2 alpha 1 (CSNK2A1) antibodyCSNK2A1 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 2B6 unconjugated Recombinant Antibody
anti-Casein Kinase 2 alpha 1 (CSNK2A1) (pSer362), (pThr360) antibodyCSNK2A1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
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别名
- CSNK2A1
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背景
- Synonyms:Casein kinase II subunit alpha, CK II alpha, CK2a, CK2A1, CK2α, CKII, CSNK2A1 Background:Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint(SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry(PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue(PubMed:24962073).
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分子量
- 45 kDa
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基因ID
- 1457
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UniProt
- P68400
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途径
- SARS-CoV-2 Protein Interactome
抗原
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