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APP 抗体 (AA 1-300)

Name: APP 抗体 (AA 1-300)
Brand: antibodies-online
SKU: ABIN7111534
Availability: OutOfStock

This 小鼠单克隆 antibody specifically detects APP in WB, ELISA 和 IHC. It exhibits reactivity toward 人和 Pig.

产品编号 ABIN7111534

发货至: 中国

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Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for APP 抗体 (AA 1-300) (ABIN7111534)

抗原

See all APP 抗体

APP (Amyloid beta (A4) Precursor Protein (APP))

适用

人, Pig

宿主

小鼠

克隆类型

单克隆

标记

This APP antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

克隆位点

8B9

Discover our top product APP Primary Antibody

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AA 1-300

原理

APP antibody

纯化方法

Protein A+G purification

纯度

≥95 % as determined by SDS-PAGE

免疫原

Immunogen sequence: 1-300aa
Immunogen: amyloid beta A4 precursor protein

亚型

IgG2a
anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody
APP 适用: 人 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) antibody
APP 适用: 人, 小鼠 WB, ELISA, IHC, IF, FM 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) antibody
APP 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-270) antibody
APP 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody
APP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 381-480) antibody
APP 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (pThr668) antibody
APP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) antibody
KD Validated APP 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1535 unconjugated Recombinant Antibody

anti-Amyloid beta (A4) Precursor Protein (APP) antibody
APP 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody
APP 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:500-1:2000, IHC: 1:50-1:500

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze / thaw cycles.

储存条件

-20 °C

储存方法

-20°C for 12 months

有效期

12 months
抗原

APP (Amyloid beta (A4) Precursor Protein (APP))

别名

APP

背景

Synonyms: Amyloid-beta precursor protein (APP)|ABPP|APPI|Alzheimer disease amyloid A4 protein homolog|Alzheimer disease amyloid protein|Amyloid precursor protein|Amyloid-beta (A4) precursor protein|Amyloid-beta A4 protein|Cerebral vascular amyloid peptide (CVAP)|PreA4|Protease nexin-II (PN-II)|N-APP|Soluble APP-alpha (S-APP-alpha)|Soluble APP-beta (S-APP-beta)|C99 Alternative names: Beta-secretase C-terminal fragment (Beta-CTF)|Amyloid-beta protein 42 (Abeta42) Alternative names: Beta-APP42|Amyloid-beta protein 40 (Abeta40) Alternative names: Beta-APP40|C83 Alternative names: Alpha-secretase C-terminal fragment (Alpha-CTF)|P3(42)|P3(40)|C80|Gamma-secretase C-terminal fragment 59 Alternative names: Amyloid intracellular domain 59 (AICD-59, AID(59))|Gamma-CTF(59)|Gamma-secretase C-terminal fragment 57 Alternative names: Amyloid intracellular domain 57 (AICD-57, AID(57))|Gamma-CTF(57)|Gamma-secretase C-terminal fragment 50 Alternative names: Amyloid intracellular domain 50 (AICD-50, AID(50))|Gamma-CTF(50)|C31|APP|A4|AD1
Background: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.

分子量

100 kDa

基因ID

351

UniProt

P05067

途径

Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour