AJUBA 抗体
Quick Overview for AJUBA 抗体 (ABIN7111418)
抗原
See all AJUBA 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- AJUBA antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- jub, ajuba homolog
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亚型
- IgG
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anti-Ajuba LIM Protein (AJUBA) (AA 61-77) antibody
AJUBA 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ajuba LIM Protein (AJUBA) antibodyAJUBA 适用: 人 WB, IP 宿主: 小鼠 Monoclonal 21G4 unconjugated
anti-Ajuba LIM Protein (AJUBA) (AA 1-538) antibodyAJUBA 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:2000, IHC: 1:20-200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- AJUBA (Ajuba LIM Protein (AJUBA))
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别名
- AJUBA
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背景
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Synonyms: LIM domain-containing protein ajuba|AJUBA|JUB
Background: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA(miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.
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分子量
- 57 kDa
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基因ID
- 84962
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UniProt
- Q96IF1
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途径
- Chromatin Binding, Cell-Cell Junction Organization
抗原
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