AP2A2 抗体
Quick Overview for AP2A2 抗体 (ABIN7111308)
抗原
See all AP2A2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- AP2A2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- adaptor-related protein complex 2, alpha 2 subunit
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亚型
- IgG
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anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 590-939) antibody
AP2A2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 590-939) antibodyAP2A2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 21-150) antibodyAP2A2 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (Internal Region) antibodyAP2A2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 610-637) antibodyAP2A2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22030 unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) antibodyAP2A2 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 612-661) antibodyAP2A2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (C-Term) antibodyAP2A2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
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别名
- AP2A2
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背景
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Synonyms: AP-2 complex subunit alpha-2|100 kDa coated vesicle protein C|Adaptor protein complex AP-2 subunit alpha-2|Adaptor-related protein complex 2 subunit alpha-2|Alpha-adaptin C|Alpha2-adaptin|Clathrin assembly protein complex 2 alpha-C large chain|Huntingtin yeast partner J|Huntingtin-interacting protein 9 (HIP-9)|Huntingtin-interacting protein J|Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit|AP2A2|ADTAB|CLAPA2|HIP9|HYPJ|KIAA0899
Background: Component of the adaptor protein complex 2(AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin(clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein(AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV](Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif(By similarity).
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分子量
- 104 kDa
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基因ID
- 161
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UniProt
- O94973
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome
抗原
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