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AP2A2 抗体 (AA 590-939)

AP2A2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7144362
发货至: 中国
  • 抗原 See all AP2A2 抗体
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    抗原表位
    • 15
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 590-939
    适用
    • 41
    • 29
    • 12
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 40
    • 1
    克隆类型
    • 41
    多克隆
    标记
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
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    This AP2A2 antibody is un-conjugated
    应用范围
    • 33
    • 13
    • 13
    • 12
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    交叉反应
    人, 小鼠
    纯化方法
    Antigen Affinity Purified
    免疫原
    Recombinant Human AP-2 complex subunit alpha-2 protein (590-939AA)
    亚型
    IgG
    Top Product
    Discover our top product AP2A2 Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    别名
    AP2A2 (AP2A2 产品)
    别名
    MGC99219 antibody, ADTAB antibody, CLAPA2 antibody, HIP-9 antibody, HIP9 antibody, HYPJ antibody, 2410074K14Rik antibody, AF006990 antibody, AW146353 antibody, Adtab antibody, C78001 antibody, L25 antibody, adaptor related protein complex 2 alpha 2 subunit antibody, adaptor related protein complex 2 alpha 2 subunit L homeolog antibody, adaptor-related protein complex 2, alpha 2 subunit antibody, AP2A2 antibody, ap2a2.L antibody, Ap2a2 antibody
    背景

    Background: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).

    Aliases: 100 kDa coated vesicle protein C antibody, Adaptor protein complex AP-2 subunit alpha-2 antibody, Adaptor-related protein complex 2 subunit alpha-2 antibody, Alpha-adaptin C antibody, Alpha2-adaptin antibody, AP-2 complex subunit alpha-2 antibody, Ap2a2 antibody, AP2A2_HUMAN antibody, Clathrin assembly protein complex 2 alpha-C large chain antibody, HIP-9 antibody, Huntingtin yeast partner J antibody, Huntingtin-interacting protein 9 antibody, Huntingtin-interacting protein J antibody, Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit antibody

    UniProt
    O94973
    途径
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome
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