ATF6B 抗体
Quick Overview for ATF6B 抗体 (ABIN7111248)
抗原
See all ATF6B 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ATF6B antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- activating transcription factor 6 beta
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亚型
- IgG
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应用备注
- WB: 1:1000-1:4000, IP:1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ATF6B (Activating Transcription Factor 6 beta (ATF6B))
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别名
- ATF6B
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背景
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Synonyms: Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta)|Activating transcription factor 6 beta (ATF6-beta)|Protein G13|cAMP response element-binding protein-related protein (Creb-rp)|cAMP-responsive element-binding protein-like 1|Processed cyclic AMP-dependent transcription factor ATF-6 beta|ATF6B|CREBL1|G13
Background: The endoplasmic reticulum (ER)-transmembrane proteins, ATF6 alpha (ATF6) and ATF6 beta (ATF6B), are cleaved during the ER stress response (ERSR). The resulting N-terminal fragments of both ATF6 isoforms, which have conserved basic leucine-zipper and DNA binding domains but divergent transcriptional activation domains, translocate to the nucleus where they bind to ER stress-response elements (ERSE) in ERSR, such as Bip/GRP78. This antibody could recognize ATF6 beta (110kd) and its cleaved forms(60,80kd )(PMID: 11256944)
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分子量
- 110 kDa, 60 kDa, 80 kDa
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基因ID
- 1388
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UniProt
- Q99941
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途径
- Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction
抗原
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