ATF6 抗体
Quick Overview for ATF6 抗体 (ABIN7111246)
抗原
See all ATF6 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ATF6 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- activating transcription factor 6
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ATF6 (Activating Transcription Factor 6 (ATF6))
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别名
- ATF6
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背景
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Synonyms: Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha)|Activating transcription factor 6 alpha (ATF6-alpha)|Processed cyclic AMP-dependent transcription factor ATF-6 alpha|ATF6
Background: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response(UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element(ERSE)(5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II(5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
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分子量
- 90 kDa
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基因ID
- 22926
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UniProt
- P18850
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途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
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