ABL2 抗体
Quick Overview for ABL2 抗体 (ABIN7111170)
抗原
See all ABL2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ABL2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- v-abl Abelson murine leukemia viral oncogene homolog 2(arg, Abelson-related gene)
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亚型
- IgG
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anti-ABL2 (ABL2) (AA 743-842) antibody
ABL2 适用: 人 WB, ELISA, PLA, RNAi 宿主: 小鼠 Monoclonal 6D5 unconjugated
anti-ABL2 (ABL2) (AA 743-842) antibodyABL2 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 5C6 unconjugated
anti-ABL2 (ABL2) antibodyABL2 适用: 人, 小鼠 ELISA, ICC 宿主: 小鼠 Monoclonal 1H1 unconjugated
anti-ABL2 (ABL2) antibodyABL2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1H1B11 unconjugated
anti-ABL2 (ABL2) (pTyr393), (pTyr439) antibodyABL2 适用: 人 WB, IHC (p), DB 宿主: 兔 Polyclonal RB7532 unconjugated
anti-ABL2 (ABL2) antibodyABL2 适用: 人, 小鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-ABL2 (ABL2) (AA 1011-1044), (C-Term) antibodyABL2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB50829 unconjugated
anti-ABL2 (ABL2) (AA 862-1064) antibodyABL2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ABL2 (ABL2) (AA 1-1167) antibodyABL2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-ABL2 (ABL2) (Tyr251) antibodyABL2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:5000, IHC: 1:20-1:200, IF: 1:10-1:100, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ABL2
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别名
- ABL2
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背景
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Synonyms: Tyrosine-protein kinase ABL2|Abelson murine leukemia viral oncogene homolog 2|Abelson tyrosine-protein kinase 2|Abelson-related gene protein|Tyrosine-protein kinase ARG|ABL2|ABLL|ARG
Background: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10(involved in movement), CTTN(involved in signaling), or TUBA1 and TUBB(microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
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分子量
- 127 kDa
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基因ID
- 27
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UniProt
- P42684
抗原
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