AKAP8L 抗体
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北京 101111
Quick Overview for AKAP8L 抗体 (ABIN7111158)
抗原
See all AKAP8L 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- AKAP8L antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- A kinase(PRKA) anchor protein 8-like
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亚型
- IgG
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anti-A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L) (C-Term) antibody
AKAP8L 适用: 人, 犬, 大鼠, 马, Cow, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L) (AA 1-240) antibodyAKAP8L 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L) (C-Term) antibodyAKAP8L 适用: 人, 小鼠, 犬, 大鼠, 马, Cow, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L) (AA 351-400) antibodyAKAP8L 适用: 人, 犬, 大鼠, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L) (AA 485-512), (C-Term) antibodyAKAP8L 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB36906 unconjugated
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应用备注
- WB: 1:200-1:2000, IF: 1:20-200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- AKAP8L (A Kinase (PRKA) Anchor Protein 8-Like (AKAP8L))
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别名
- AKAP8L
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背景
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Synonyms: A-kinase anchor protein 8-like (AKAP8-like protein)|Helicase A-binding protein 95 (HAP95)|Homologous to AKAP95 protein (HA95)|Neighbor of A-kinase-anchoring protein 95 (Neighbor of AKAP95)|AKAP8L|NAKAP|NAKAP95
Background: Could play a role in constitutive transport element(CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export(PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA(PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis(PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta(PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3, in this function seems to act redundantly with AKAP8(PubMed:16980585). May be involved in regulation of pre-mRNA splicing(PubMed:17594903). (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters(PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses(PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription, in vitro negatively regulates DHX9 annealing activity(PubMed:25034436).
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分子量
- 72 kDa
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基因ID
- 26993
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UniProt
- Q9ULX6
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途径
- SARS-CoV-2 Protein Interactome
抗原
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