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HNRNPK 抗体 (AA 201-300) (Biotin)

This anti-HNRNPK antibody is a 兔 多克隆 antibody detecting HNRNPK in WB, ELISA, IHC (p) 和 IHC (fro). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN706573
发货至: 中国

Quick Overview for HNRNPK 抗体 (AA 201-300) (Biotin) (ABIN706573)

抗原

See all HNRNPK 抗体
HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This HNRNPK antibody is conjugated to Biotin

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 201-300

    交叉反应

    人, 小鼠, 大鼠

    预测反应

    Dog,Cow,Pig,Chicken,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human hnRNP K

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

    别名

    hnRNP K

    背景

    Synonyms: CSBP, TUNP, HNRPK, Heterogeneous nuclear ribonucleoprotein K, hnRNP K, Transformation up-regulated nuclear protein, HNRNPK

    Background: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

    基因ID

    3190

    UniProt

    P61978
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