RAD21 抗体 (AA 531-631) (Biotin)
Quick Overview for RAD21 抗体 (AA 531-631) (Biotin) (ABIN706393)
抗原
See all RAD21 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 531-631
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交叉反应
- 人, 大鼠
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预测反应
- Mouse,Dog,Cow,Pig,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Rad2
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亚型
- IgG
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- RAD21 (RAD21 Homolog (RAD21))
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别名
- RAD21
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背景
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Synonyms: HR21, MCD1, NXP1, SCC1, CDLS4, hHR21, HRAD21, Double-strand-break repair protein rad21 homolog, Nuclear matrix protein 1, NXP-1, SCC1 homolog, RAD21, KIAA0078
Background: Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
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基因ID
- 5885
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UniProt
- O60216
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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