tau 抗体 (pThr217) (Biotin)
Quick Overview for tau 抗体 (pThr217) (Biotin) (ABIN7091996)
抗原
See all tau 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr217
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交叉反应
- 人
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纯化方法
- affinity Purified by Protein A.
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免疫原
- KLH conjugated Synthesised phosphopeptide derived from human Tau around the phosphorylation site of Thr4217)
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亚型
- IgG
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应用备注
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WB 1:300-5000
IHC-P 1:200-400 -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- tau (tau Protein)
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别名
- Tau
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背景
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Synonyms: Tau(Phospho-Thr217), MAPT(phospho T217),Tau(Phospho-Thr217), MAPT, Microtuble-associted protein Tau, AI413597, AW045860, DDPAC, Disinhibition dementia parkinsonism amyotrophy complex, FLJ31424, FTDP 17, FTDP17, G Protein beta 1 gamma 2 subunit interacting factor 1, G protein beta1/gamma2 subunit interacting factor 1, MAPTL, MGC134287, MGC138549, MGC156663, Microtubule associated protein tau isoform 4, MSTD, Mtapt, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament tau, PHF tau, PHF-tau, PPND, pTau, RNPTAU, Tauopathy and respiratory failure, included, TAU_HUMAN.
Background: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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基因ID
- 4137
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UniProt
- P10636
抗原
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