Recombinant FGFR2 抗体
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北京 101111
Quick Overview for Recombinant FGFR2 抗体 (ABIN7091110)
抗原
See all FGFR2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
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原理
- FGFR2 Recombinant Antibody
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预测反应
- Human,Mouse,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FGFR2
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亚型
- IgG
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应用备注
- IHC-P(IHC-P=1:400-800), IHC-F(1:100-500), IF()
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
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别名
- FGFR2
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背景
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Synonyms: KGFR, KSAM, Bacteria expressed kinase, BEK, BEK fibroblast growth factor receptor, BFR 1, BFR1, CD 332, CD332, CD332 antigen, CEK 3, CEK3, CFD 1, CFD1, Craniofacial dysostosis 1, Crouzon syndrome, ECT 1, ECT 1, ECT1, FGF receptor, FGFR 2, FGFR-2, FGFR2_HUMAN, Fibroblast growth factor receptor 2, Hydroxyaryl protein kinase, Hydroxyaryl protein kinase, Jackson Weiss syndrome, JWS, JWS antibody K SAM, K sam protein, K sam protein, K-sam , Keratinocyte growth factor receptor 2, Keratinocyte growth factor receptor, Pfeiffer syndrome, Protein tyrosine kinase receptor like 14, TK14, TK25, Tyrosylprotein kinase, Tyrosylprotein kinase.
Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
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基因ID
- 2263
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UniProt
- P21802
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding
抗原
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