TCF7 抗体
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北京 101111
Quick Overview for TCF7 抗体 (ABIN7075952)
抗原
See all TCF7 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 大鼠
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Mouse TCF7
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应用备注
- IHC/IF (M,R) 1:600-1:1200/1:600-1:1200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))
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别名
- TCF7
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背景
- TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
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基因ID
- 21414
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NCBI登录号
- NP_001300910
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UniProt
- Q00417
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途径
- WNT signaling
抗原
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