SAV1 抗体
Quick Overview for SAV1 抗体 (ABIN7075505)
抗原
See all SAV1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 大鼠
-
纯化方法
- Affinity purification
-
免疫原
- Recombinant protein corresponding to Mouse SAV1
-
-
-
-
应用备注
- IHC/IF (M,R) 1:200-1:1400
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
-
- SAV1 (Salvador Homolog 1 (SAV1))
-
别名
- SAV1
-
背景
- WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
-
基因ID
- 64010
-
NCBI登录号
- NP_071311
-
UniProt
- Q8VEB2
-
途径
- Stem Cell Maintenance
抗原
-