PARN 抗体
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北京 101111
Quick Overview for PARN 抗体 (ABIN7075117)
抗原
See all PARN 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Mouse PARN
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应用备注
- WB (H,M) 1:500-1:1000, IHC/IF (H) 1:900-1:1800
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- PARN (Poly A Specific Ribonuclease (PARN))
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别名
- PARN
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背景
- The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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分子量
- 76 kDa
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基因ID
- 74108
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UniProt
- Q8VDG3
抗原
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