PNN 抗体
Our Local Distributor
北京 101111
Quick Overview for PNN 抗体 (ABIN7075083)
抗原
See all PNN 抗体适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 人, 大鼠
-
纯化方法
- Affinity purification
-
免疫原
- KLH conjugated Synthetic peptide corresponding to Mouse PNN/DRSP
-
-
-
-
应用备注
- IHC/IF (H,M,R) 1:600-1:1200/1:400-1:800
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
-
- PNN (Pinin, Desmosome Associated Protein (PNN))
-
别名
- PNN/DRSP
-
背景
- PNN, also named as DRS or 140 kDa nuclear and cell adhesion-related phosphoprotein, is a 717 amino acid protein, which belongs to the pinin family. PNN localizes in the plasma membrane and is expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. PNN is expressed strongly in melanoma metastasis lesions and advanced primary tumors. PNN as a transcriptional activator binds to the E-box 1 core sequence of the E-cadherin promoter gene. PNN is involved in the establishment and maintenance of epithelia cell-cell adhesion. PNN is a potential tumor suppressor for renal cell carcinoma.
-
基因ID
- 18949
-
NCBI登录号
- NP_032917
-
UniProt
- O35691
抗原
-