MPL 抗体
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北京 101111
Quick Overview for MPL 抗体 (ABIN7074718)
抗原
See all MPL 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 大鼠
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纯化方法
- Affinity purification
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免疫原
- KLH conjugated Synthetic peptide corresponding to Mouse TPOR
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应用备注
- IHC/IF (M,R) 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
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别名
- TPOR/MPL
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背景
- The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
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基因ID
- 17480
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NCBI登录号
- NP_001116421
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UniProt
- Q08351
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途径
- JAK/STAT Signaling
抗原
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