CRTC1 抗体
Our Local Distributor
北京 101111
Quick Overview for CRTC1 抗体 (ABIN7073590)
抗原
See all CRTC1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 大鼠
-
纯化方法
- Affinity purification
-
免疫原
- KLH conjugated Synthetic peptide corresponding to Mouse TORC1
-
-
-
-
应用备注
- IHC/IF (M,R) 1:400-1:800
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
-
- CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
-
别名
- TORC1
-
背景
- CRTC1, also named as MECT1, TORC1, and WAMTP1, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. CRTC1 acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. It enhances the interaction of CREB1 with TAF4. CRTC1 regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. It is a potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.
-
基因ID
- 382056
-
NCBI登录号
- NP_001004062
-
UniProt
- Q68ED7
抗原
-