BPTF 抗体
Quick Overview for BPTF 抗体 (ABIN7073234)
抗原
See all BPTF 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 小鼠, 大鼠
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Human BPTF
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anti-Bromodomain PHD Finger Transcription Factor (BPTF) (AA 2801-3046) antibody
BPTF 适用: 小鼠, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain PHD Finger Transcription Factor (BPTF) antibodyBPTF 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2F10 unconjugated
anti-Bromodomain PHD Finger Transcription Factor (BPTF) antibodyBPTF 适用: 人 DB 宿主: 小鼠 Monoclonal 2343C3a unconjugated
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应用备注
- IHC/IF (H,M,R) 1:500-1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))
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别名
- BPTF/FALZ
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背景
- FALZ/BPTF is a histone-binding component of NURF (nucleosome remodeling factor), a complex that catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. This gene was identified in brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), containing a DNA-binding domain, a zinc finger motif, and a C-terminal bromodomain, suggested it might play a role in the regulation of transcription during proliferation. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. This protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription.
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基因ID
- 2186
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NCBI登录号
- NP_004450
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UniProt
- Q12830
抗原
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