(2 references)-
- 抗原 See all BPTF 抗体
- BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This BPTF antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- purified
- 免疫原
- Purified recombinant fragment of human BPTF expressed in E. coli.
- 克隆位点
- 2F10
- 亚型
- IgG2b
- Top Product
- Discover our top product BPTF Primary Antibody
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anti-Bromodomain PHD Finger Transcription Factor (BPTF) (AA 2801-3046) antibody
BPTF 适用: 小鼠, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain PHD Finger Transcription Factor (BPTF) antibodyBPTF 适用: 人 IHC (p), IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- ELISA: 1:10000, WB: 1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- 4°C, -20°C for long term storage
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: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." in: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).
: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, (2008) (PubMed).
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: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." in: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).
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- 抗原
- BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))
- 别名
- BPTF (BPTF 产品)
- 别名
- FAC1 antibody, FALZ antibody, NURF301 antibody, 9430093H17Rik antibody, Falz antibody, BPTF antibody, bromodomain PHD finger transcription factor antibody, nucleosome-remodeling factor subunit NURF301 antibody, fetal alzheimer antigen, falz antibody, BPTF antibody, Bptf antibody, LOC5576547 antibody, CpipJ_CPIJ011285 antibody, bptf antibody
- 背景
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Description: BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level) .Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
Aliases: FAC1, FALZ, NURF301, BPTF
- 分子量
- 338 kDa
- 基因ID
- 2186
- HGNC
- 2186
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