Recombinant TNFSF9 抗体
Quick Overview for Recombinant TNFSF9 抗体 (ABIN7072494)
抗原
See all TNFSF9 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-4-1BBL [AT113-2], Rat IgG1, kappa
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特异性
- This antibody is specific for 4-1BB ligand (also known as CD137 ligand), which is a member of the TNF superfamily and is a type II membrane protein. 4-1BB ligand is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation of these cells. Both of the 4-1BB ligand and its receptor, TNFRSF9/4-1BB, are involved in the antigen presentation process and in the generation of cytotoxic T cells. In direct ELISAs, no cross-reactivity with recombinant human RELT is observed.
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产品特性
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Original Species of Ab: Rat
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- This antibody was raised by immunising LOU rats with soluble recombinant 4-1BBL:Fc fusion protein.
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亚型
- IgG1 kappa
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anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 101-200) antibody
TNFSF9 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 42-253) antibodyTNFSF9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 105-309) antibodyTNFSF9 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) antibodyTNFSF9 适用: 人 FACS, IHC, StM 宿主: 小鼠 Monoclonal CD137L-1547 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 52-254) antibodyTNFSF9 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM68 unconjugated Recombinant Antibody
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (Extracellular Domain) antibodyTNFSF9 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 41B436 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 52-254) antibodyTNFSF9 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 145-254) antibodyTNFSF9 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 145-254) antibodyTNFSF9 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- This antibody has been used in various FACS analyses, for instance, to show that CD27:CD70 and 4-1BB:4-1BBL interactions are needed for dendritic cell-driven accumulation of antitumor cytotoxic T lymphocytes following anti-CD40 mAb treatment (French et al, 2007), to examine the underlying mechanisms of the differential T cell costimulation dependence in viral infections (Welten et al, 2015), and to explore the therapeutic benefit of using combinations of syngeneic tumor vaccines that express immune modulators (Manrique-Rincón et al, 2017). This antibody has been used as a blocking antibody, together with anti-CD70, anti-CD30L and anti-OX40L antibodies, to evaluate OX40 ligand and CD70 in the promotion of CD4+ T cell responses (Kurche et al, 2010). Furthermore, this anti-4-1BBL antibody has been used alongside the anti-CD70, anti-CD27, anti-CD40 antibodies in a BCL1-bearing mouse model to evaluate the theurapeutic potency of various combined immmunotherapies against lymphoma (French et al, 2007).
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
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别名
- 4-1BBL
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背景
- CD137L, TNFSF9, 4-1BB ligand, 41BBL, CDw137L, homolog of mouse 4-1BB-L, receptor 4-1BB ligand, tumor necrosis factor (ligand) superfamily member 9, tumor necrosis factor (ligand) superfamily, member 9, tumor necrosis factor ligand 5A, Tumor necrosis factor ligand superfamily member 9.
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UniProt
- P41274
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途径
- Activated T Cell Proliferation, Cancer Immune Checkpoints
抗原
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