Recombinant TIGIT 抗体
Quick Overview for Recombinant TIGIT 抗体 (ABIN7072458)
抗原
See all TIGIT 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-TIGIT [4D4], Rabbit IgG, kappa
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特异性
- 4D4 specifically recognises TIGIT.
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产品特性
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Original Species of Ab: Hamster, Armenian
Original Format of Ab: IgG
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纯化方法
- Protein A affinity purified
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免疫原
- Armenian hamsters were immunized with recombinant mouse TIGIT tetramers by a combination of s.c. and food pad immunization and booster injections. Draining lymph nodes were fused with Sp2/0-Ag14 cells, selected in HAT (hypoxanthine/aminopterin/thymidine) medium and supernatants were screened for specificity by ELISA and flow cytometry using TIGIT-transfectants.
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亚型
- IgG kappa
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anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 21-234) antibody
TIGIT 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 IHC, ELISA, FACS, Coat, StM 宿主: 小鼠 Monoclonal TIGIT-3017 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4C5B9 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 28-246) antibodyTIGIT 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal TIGIT-3106 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 28-227) antibodyTIGIT 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) antibodyTIGIT 适用: 小鼠 ELISA, FACS, BP 宿主: 兔 Chimeric 1B4 unconjugated Recombinant Antibody
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM178 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 12-142) antibodyTIGIT 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB55818 unconjugated
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应用备注
- 4D4 is an agonistic anti-TIGIT antibody, and addition of plate bound 4D4 to anti-CD3/anti-CD28 stimulated T cells was shown to inhibit their proliferation (Joller 2011). Further, 4D4 has been used in order to identify genes that are downstream of TIGIT signaling in Tregs, as TIGIT engagement might modulate the Treg phenotype in tumor tissue (Liu 2016).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Hamster format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
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别名
- TIGIT
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背景
- VSIG9, T Cell Immunoreceptor With Ig And ITIM Domains, V-Set And Immunoglobulin Domain Containing Protein 9, V-Set And Transmembrane Domain Containing Protein 3, VSTM3, T Cell Immunoreceptor With Ig And ITIM Domains, Washington University Cell Adhesion Molecule, WUCAM
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UniProt
- P86176
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途径
- Cancer Immune Checkpoints
抗原
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