Recombinant Integrin beta 7 抗体
Quick Overview for Recombinant Integrin beta 7 抗体 (ABIN7072355)
抗原
See all Integrin beta 7 (ITGB7) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Integrin beta-7 [FIB27], Rabbit IgG, kappa
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特异性
- FIB27 binds specifically to both human and mouse integrin beta-7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta-7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
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交叉反应
- 小鼠
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产品特性
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Original Species of Ab: Rat
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- FIB27 was prepared by immunizing rats with TK1 cells.
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亚型
- IgG kappa
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anti-Integrin beta 7 (ITGB7) (AA 1-798) antibody
ITGB7 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 7 (ITGB7) (AA 1-140) antibodyITGB7 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 7 (ITGB7) (Internal Region) antibodyITGB7 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 7 (ITGB7) (AA 721-806) antibodyITGB7 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 7 (ITGB7) antibodyITGB7 适用: 人, 小鼠 FACS 宿主: 大鼠 Monoclonal FIB504 unconjugated
anti-Integrin beta 7 (ITGB7) antibodyITGB7 适用: 人, 小鼠 FACS, IF, BR 宿主: 兔 Chimeric FIB504 unconjugated Recombinant Antibody
anti-Integrin beta 7 (ITGB7) (AA 401-505) antibodyITGB7 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 8D3 unconjugated
anti-Integrin beta 7 (ITGB7) (AA 1-798) antibodyITGB7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Integrin beta 7 (ITGB7) (AA 737-765) antibodyITGB7 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- FIB27 can be used for FC, IP and can block TKI cell aggregation and beta-7 intergrin-mediated cell adhesion.
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Integrin beta 7 (ITGB7)
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别名
- Integrin beta-7
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背景
- FIB-27, FIB 27, Fib-27, Fib27, Fib 27, fib27, fib-27, fib 27, Integrin b7, integrin b-7, ITGB7, Gut homing receptor beta subunit
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途径
- Integrin Complex
抗原
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