Recombinant Galanin 抗体 (C-Term)
Quick Overview for Recombinant Galanin 抗体 (C-Term) (ABIN7072341)
抗原
See all Galanin (GAL) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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原理
- Anti-Galanin [4B3], Mouse IgG1, kappa
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特异性
- The antibody binds to galanin with an affinity constant (Kd) of 0.07 nM reported for the original antibody.
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交叉反应
- 小鼠
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- C-terminal fusions of KLH to human galanin,
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亚型
- IgG1 kappa
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anti-Galanin (GAL) (AA 32-122) antibody
GAL 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Galanin (GAL) (AA 36-123) antibodyGAL 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Galanin (GAL) (AA 55-86), (Middle Region) antibodyGAL 适用: 人 WB, IF, EIA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Galanin (GAL) (AA 33-62) antibodyGAL 适用: 大鼠 ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Galanin (GAL) (AA 26-121) antibodyGAL 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Galanin (GAL) (AA 48-79) antibodyGAL 适用: 人 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Galanin (GAL) antibodyGAL 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Galanin (GAL) (AA 36-85) antibodyGAL 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 4B3 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned.
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说明
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This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Galanin (GAL)
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别名
- Galanin
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背景
- Gal peptide
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UniProt
- P22466
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途径
- Regulation of Hormone Metabolic Process, Feeding Behaviour
抗原
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