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Recombinant BACE2 抗体

This anti-BACE2 antibody is a 小鼠 单克隆 antibody detecting BACE2 in WB 和 IHC. Suitable for 人.
产品编号 ABIN7072331
发货至: 中国

Quick Overview for Recombinant BACE2 抗体 (ABIN7072331)

抗原

See all BACE2 抗体
BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

抗体类型

Recombinant Antibody

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This BACE2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)

克隆位点

1-9
  • 原理

    Anti-BACE2 [1/ 9 ], Mouse IgG1, kappa

    产品特性

    Original Species of Ab: Mouse

    Original Format of Ab: IgG

    纯化方法

    Protein A affinity purified

    免疫原

    Human BACE2 244-333.

    亚型

    IgG1 kappa
  • 应用备注

    The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease.

    说明

    This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    PBS with 0.02 % Proclin 300.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原

    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

    别名

    BACE2

    背景

    Beta-secretase 2, Aspartic-like protease, Aspartyl protease 1, Asp1, Beta-site amyloid precursor protein cleaving enzyme 2, Down syndrome aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, theta-secretase

    UniProt

    Q9Y5Z0
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