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Recombinant CD28 抗体

Name: Recombinant CD28 抗体
Brand: antibodies-online
SKU: ABIN7072327
Availability: OutOfStock

This anti-CD28 antibody is a 小鼠单克隆 antibody detecting CD28 in FACS, ELISA, Func, Act, BP 和 in vivo. Suitable for 犬.

产品编号 ABIN7072327

发货至: 中国

Quick Overview for Recombinant CD28 抗体 (ABIN7072327)

抗原

See all CD28 抗体

CD28

抗体类型

Recombinant Antibody

适用

犬

宿主

小鼠

克隆类型

单克隆

标记

This CD28 antibody is un-conjugated

应用范围

Flow Cytometry (FACS), ELISA, Functional Studies (Func), Activation (Act), Blocking Peptide (BP), In vivo Studies (in vivo)

克隆位点

1C6

Discover our top product CD28 Primary Antibody

原理

Anti-CD28 [1C6], Mouse IgG1, kappa

特异性

The antibody binds specifically to canine CD28, a self-surface receptor expressed by thymocytes and a subset of natural killer cells. CD28 acts as a receptor for CD80 and CD86, providing a costimulatory signal for the activation of T-cells and the production of interleukins, such as IL-6.

产品特性

Original Species of Ab: Mouse
Original Format of Ab: IgG1

纯化方法

Protein A affinity purified

免疫原

Canine CD28.

亚型

IgG1 kappa
anti-CD28 (CD28) (AA 1-120) antibody
CD28 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (fro), IF (p), IHC (p), IF (cc) 宿主: 兔 Polyclonal unconjugated

anti-CD28 (CD28) antibody
CD28 适用: 人, Non-Human Primate FACS, WB, IP, IHC (fro), ICC 宿主: 小鼠 Monoclonal CD28-2 unconjugated

anti-CD28 (CD28) antibody (FITC)
CD28 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal CD28-2 FITC

anti-CD28 (CD28) antibody
CD28 适用: 人, Non-Human Primate FACS, WB, IP, Func, IHC (fro), ICC 宿主: 小鼠 Monoclonal CD28-2 unconjugated

anti-CD28 (CD28) (AA 19-152) antibody
CD28 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM61 unconjugated Recombinant Antibody

anti-CD28 (CD28) (Internal Region) antibody
Verified CD28 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-CD28 (CD28) antibody
CD28 适用: 大鼠 FACS, IP 宿主: 小鼠 Monoclonal JJ319 unconjugated

anti-CD28 (CD28) antibody
CD28 适用: 人 FACS, IF, Func 宿主: 小鼠 Monoclonal CB28 unconjugated

anti-CD28 (CD28) antibody
CD28 适用: 人, 小鼠, Cow, Pig, 绵羊 FACS, IF, Func 宿主: 小鼠 Monoclonal 204-12 unconjugated

anti-CD28 (CD28) (C-Term) antibody
CD28 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

This antibody exhibits an antagonistic activity, blocking mixed lymphocyte reactions and cytotoxic T lymphocyte-mediated killing. The use of this antibody to neutralize the CD26 signal following T-cell receptor activation is of clinical importance for transplantation therapy, as it has been shown to prevent graft rejection and graft-versus-host disease in the canine model of allogeneic hematopoietic cell transplantation (HCT). Interestingly, this antibody also exhibits agnostic activity, it was coated onto magnetic beads and used for the activation of canine peripheral blood lymphocytes (Szopa et al., 2021, PMID: 33679741).

限制

仅限研究用
浓度

1 mg/mL

缓冲液

PBS with 0.02 % Proclin 300.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
抗原

CD28

别名

CD28

背景

TP44, Costimulatory molecule B7 receptor CD28, T-cell costimulatory molecule CD28

UniProt

Q9N0N8

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response