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Recombinant CD28 抗体

This anti-CD28 antibody is a 兔 Chimeric antibody detecting CD28 in FACS, IHC, SPR, CoSt 和 Agon. Suitable for 小鼠.
产品编号 ABIN7072237
发货至: 中国

Quick Overview for Recombinant CD28 抗体 (ABIN7072237)

抗原

See all CD28 抗体
CD28

抗体类型

Recombinant Antibody

适用

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宿主

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克隆类型

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Chimeric

标记

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This CD28 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunohistochemistry (IHC), Surface Plasmon Resonance (SPR), Co-Stimulation (CoSt), Agonist (Agon)

克隆位点

D665
  • 原理

    Anti-CD28 [D665], Rabbit IgG, kappa

    特异性

    This antibody binds to the laterally exposed C'D loop of CD28 and induces T cell proliferation without TCR ligation.

    产品特性

    Original Species of Ab: Mouse

    Original Format of Ab: IgG1

    纯化方法

    Protein A affinity purified

    免疫原

    The original D665 antibody was generated by immunizing mice alternately with A20 cells expressing mCD28 i.p. and with recombinant mCD28Ig s.c.

    亚型

    IgG kappa
  • 应用备注

    This antibody binds to mouse CD28. The original mouse IgG1 version was shown to trigger T-cell proliferation in vitro and in vivo in a TCR-independent manner and is a superagonistic antibody. This antibody does not compete with E18 (Ab00286).

    说明

    This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    PBS with 0.02 % Proclin 300.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原

    CD28

    别名

    CD28

    背景

    TP44, T-cell-specific surface glycoprotein CD28, TP44

    UniProt

    P31041

    途径

    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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