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VIPR2 抗体 (Extracellular)

VIPR2 适用: 人 WB, IF, IC, IF (cc), LCI 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7043877
发货至: 中国
  • 抗原 See all VIPR2 抗体
    VIPR2 (Vasoactive Intestinal Peptide Receptor 2 (VIPR2))
    抗原表位
    • 10
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 25-37, Extracellular
    适用
    • 32
    • 9
    • 6
    • 1
    • 1
    宿主
    • 28
    • 6
    克隆类型
    • 28
    • 5
    多克隆
    标记
    • 25
    • 3
    • 2
    • 2
    • 1
    • 1
    This VIPR2 antibody is un-conjugated
    应用范围
    • 25
    • 25
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)
    原理
    A Rabbit Polyclonal Antibody to VPAC2 Receptor
    特异性
    Extracellular, N-terminus
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    Mouse,rat - identical
    产品特性
    Anti-VPAC2 (VIPR2) (extracellular) Antibody is directed against an extracellular epitope of human VIP and PACAP receptor 2. Anti-VPAC2 (VIPR2) (extracellular) Antibody (ABIN7043877, ABIN7045331 and ABIN7045332)) can be used in western blot analysis, immunocytochemistry and indirect flow cytometry applications. It has been designed to recognize VPAC2 from human, rat and mouse samples.
    纯化方法
    Affinity purified on immobilized antigen.
    免疫原

    Immunogen: Synthetic peptide

    Immunogen Sequence: CRFHLEIQEEETK, corresponding to amino acid residues 25-37 of human VPAC2

    亚型
    IgG
    Top Product
    Discover our top product VIPR2 Primary Antibody
  • 应用备注

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:600

    说明

    Cited Application: IFC

    Negative Control: BLP-VR002

    Blocking Peptide: BLP-VR002

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4
    储存条件
    4 °C,-20 °C
    储存方法

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • 抗原
    VIPR2 (Vasoactive Intestinal Peptide Receptor 2 (VIPR2))
    别名
    VIPR2 (VIPR2 产品)
    背景
    VIP and PACAP receptor 2, Vasoactive intestinal polypeptide receptor 2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, PACAP type III receptor, PACAP-R3,Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) are prominent neuropeptides that are structurally related. Two receptors have similarly high affinity for VIP and PACAP and have therefore been termed VIP and PACAP receptor 1 (VPAC1) and VIP and PACAP receptor 2 (VPAC2). VPAC2 (also known as vasoactive intestinal peptide receptor 2) belongs to the Class II family of G-protein coupled receptors1. A distinct feature of class II GPCRs is the presence of large N-terminal extracellular domains which contain 10 highly conserved amino acids including six cysteines, putative N terminal leader sequences and several potential N-glycosylation sites1.VPAC2 receptor is expressed in the uterus, prostate, smooth muscle of the gastrointestinal tract, seminal vesicles and skin, blood vessels and thymus2. VPAC2 is also expressed in various brain regions including the thalamus and the suprachiasmatic nuclei (SCN)3.VPAC2 plays important roles in the control of mammalian circadian rhythms in the SCN. Mice lacking VPAC2 show altered circadian rhythms in locomotor behavior, neuronal firing and clock gene expression4. Recent studies have also shown that duplication of the VPAC2 gene, and the resulting higher than normal VPAC2 signaling in patients confers a significant risk to schizophrenia5.

    Alternative names: VPAC2 (VIPR2), VIP and PACAP receptor 2, Vasoactive intestinal polypeptide receptor 2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, PACAP type III receptor, PACAP-R3
    基因ID
    7434
    NCBI登录号
    NM_003382
    UniProt
    P41587
    途径
    cAMP Metabolic Process
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