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- 抗原 See all TREM2 抗体
- TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
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抗原表位
- AA 42-56, Extracellular
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TREM2 antibody is conjugated to FITC
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应用范围
- Flow Cytometry (FACS), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to TREM2 Conjugated to the Fluorescent Dye FITC
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse, rat - 12,15 amino acid residues identical,human - 14
- 产品特性
- Anti-TREM2 (extracellular) Antibody (ABIN7043865, ABIN7044666 and ABIN7044667) is a highly selective antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and live cell flow cytometry applications. The antibody recognizes an extracellular epitope and can be used to detect the protein in living cells. It has been designed to recognize TREM2 from mouse, human, and rat samples. \nAnti-TREM2 (extracellular)-FITC Antibody (ABIN7043865, ABIN7044666 and ABIN7044667)-F) is directly conjugated to fluorescein isothiocyanate (FITC). The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KHWGRRKAW(S)RQLGE, corresponding to amino acid residues 42-56 of mouse TREM2
- 亚型
- IgG
- Top Product
- Discover our top product TREM2 Primary Antibody
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anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-100) antibody
TREM2 适用: 小鼠, 人, 大鼠, Pig WB, ELISA, ICC, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-228) antibodyTREM2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-227) antibodyTREM2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (Internal Region) antibodyVerified TREM2 适用: 小鼠 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 22-48), (N-Term) antibodyTREM2 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB38661 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 42-56), (Extracellular) antibodyTREM2 适用: 小鼠 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-174) antibodyTREM2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) antibody (PE)TREM2 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal 78-18 PE
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-161) antibodyTREM2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B5 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 42-56), (Extracellular) antibody (PE)TREM2 适用: 小鼠 FACS, LCI 宿主: 兔 Polyclonal PE
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: N/A
- 说明
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Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7237532)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
- 别名
- TREM2 (TREM2 产品)
- 背景
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Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2,TREM2 (triggering receptor expressed on myeloid cells-2) is a type I transmembrane microglial surface receptor that is found to be expressed on myeloid cells including monocyte-derived dendritic cells, osteoclasts and bone-marrow derived macrophage. TREM2 protein transduces intracellular signals that regulate microglial functions such as cytokine production, migration, proliferation, phagocytosis, cell survival, synapse elimination, and compaction of amyloid plaques1,2.The TREM2 structure includes an immunoglobulin-like extracellular domain responsible for ligand binding, a transmembrane region and a short cytoplasmatic tail. The protein also includes an ectodomain that binds anionic and zwitterionic lipids, apolipoproteins and lipoprotein particles2,3.Studies show that TREM2 knockout mice display decreased levels of inflammatory cytokines. TREM2 has been shown to control two signaling pathways in the brain: regulation of phagocytosis and suppression of inflammatory reactivity. Nasu-Hakola disease, a rare and fatal disease, and polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy has been found to be linked to homozygous loss-of-function mutations in TREM2 protein1,2. Studies also show that variants of TREM2 are associated with Alzheimer's disease2,3.
Alternative names: Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2 - 基因ID
- 83433
- NCBI登录号
- NM_018965
- UniProt
- Q99NH8
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