TAAR1 抗体 (Intracellular)
Quick Overview for TAAR1 抗体 (Intracellular) (ABIN7043812)
抗原
See all TAAR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 313-325, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Trace Amine Receptor 1
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - 12,13 amino acid residues identical
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产品特性
- Anti-Trace Amine Receptor 1 (TAAR1) Antibody is directed against an epitope of the rat Trace amine-associated receptor 1. Anti-Trace Amine Receptor 1 (TAAR1) Antibody (ABIN7043812, ABIN7045324 and ABIN7045325) can be used in western blot analysis. It has been designed to recognize TAAR1 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KMVLFGKIFQKDS, corresponding to amino acid residues 313-325 of rat TAAR1
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亚型
- IgG
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anti-Trace Amine Associated Receptor 1 (TAAR1) (N-Term) antibody
TAAR1 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Trace Amine Associated Receptor 1 (TAAR1) (Cytoplasmic Domain) antibodyTAAR1 适用: 人, 猴 IHC (p), IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Trace Amine Associated Receptor 1 (TAAR1) (Extracellular Domain) antibodyTAAR1 适用: 人, 猴 WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Trace Amine Associated Receptor 1 (TAAR1) (Internal Region) antibodyTAAR1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Trace Amine Associated Receptor 1 (TAAR1) (AA 200-230) antibodyTAAR1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Trace Amine Associated Receptor 1 (TAAR1) (AA 100-200) antibodyTAAR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Trace Amine Associated Receptor 1 (TAAR1) (2nd Extracellular Domain) antibodyTAAR1 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Trace Amine Associated Receptor 1 (TAAR1) (3rd Cytoplasmic Domain) antibodyTAAR1 适用: 人 IHC (p), ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7237397)
Blocking Peptide: (ABIN7237397)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- TAAR1 (Trace Amine Associated Receptor 1 (TAAR1))
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别名
- TAAR1
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背景
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Trace amine-associated receptor 1, TaR-1, TA1, TRAR1,Trace amines are compounds, such as p-tyramine and tryptamine, found in the body in trace amounts. These substances were believed to mainly modulate aminergic pathways. However, they were found to activate Trace amino associated receptors (TAARs), members of the G-protein coupled receptor (GPCRs) superfamily1.Trace amine receptor 1 (TAAR-1) is part of the Rhodopsin family of GPCRs. Five other putative genes are thought to encode TAAR receptors. This receptor has a seven transmembrane domain with short extracellular N- and intracellular C- terminal domains.TAAR-1 couples Gs, thus leading to an increase in intracellular cAMP levels. Its signaling might be enhanced by monoamine transporters, and activation of TAAR-1 may also affect monoamine transport function. The receptor also inhibits PKA and PKC mediated dopamine uptake and PKC mediated dopamine efflux2. It is also possible that it forms heterodimers with dopamine receptors, thus influencing dopamine transmission3.In humans, this receptor is mainly expressed in the stomach but is also detected in the lungs, small intestine and many cerebral and cerebellar tissues including the amygdala, hypothalamus and others4.In experiments conducted in mice it was shown that TAAR-1 knockout mice display increased stimulation effects of d-amphetamine, greater levels of extracellular monoamine and hyperactivity. These effects are related to clinical conditions such as ADHD, psychosis and other psychiatric problems5. Additional studies on TAAR family receptors may be helpful in finding cutting edge treatment.
Alternative names: Trace Amine Receptor 1 (TAAR1), Trace amine-associated receptor 1, TaR-1, TA1, TRAR1 -
基因ID
- 113914
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NCBI登录号
- NM_138327
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UniProt
- Q923Y9
抗原
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