beta Synuclein 抗体 (Intracellular)
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Quick Overview for beta Synuclein 抗体 (Intracellular) (ABIN7043801)
抗原
See all beta Synuclein (SNCB) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 86-99, Intracellular
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原理
- A Rabbit Polyclonal Antibody to β-Synuclein
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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交叉反应 （详细）
- Specific for β-synuclein. No cross-reactivity with α-synuclein.
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Beta-Synuclein Antibody (ABIN7043801, ABIN7045182 and ABIN7045183) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize β-synuclein from human, mouse, and rat samples. The antibody is specific for β-synuclein. It will not cross-react with α-synuclein.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KEEFPTDLKPEEVA, corresponding to amino acid residues 86-99 of rat beta-synuclein
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亚型
- IgG
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anti-Synuclein, beta (SNCB) antibody
SNCB 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, beta (SNCB) (C-Term) antibodySNCB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, beta (SNCB) (AA 1-134) antibodySNCB 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3G6 unconjugated
anti-Synuclein, beta (SNCB) antibodySNCB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, beta (SNCB) (AA 1-65) antibodySNCB 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F11 unconjugated
anti-Synuclein, beta (SNCB) (AA 93-122), (C-Term) antibodySNCB 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB21263 unconjugated
anti-Synuclein, beta (SNCB) (AA 85-134) antibodySNCB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, beta (SNCB) (C-Term) antibodySNCB 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, beta (SNCB) (AA 1-134) antibodySNCB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, beta (SNCB) (C-Term) antibodySNCB 适用: 人 WB 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7237362)
Blocking Peptide: (ABIN7237362)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- beta Synuclein (SNCB) (Synuclein, beta (SNCB))
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别名
- SNCB
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背景
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β-Synuclein, Synuclein beta, PNP 14, SNCB,β-Synuclein is a presynaptic protein that plays an important role in neuronal plasticity and synaptic vesicle regulation. The synuclein family includes three members: α, β and γ isoforms. The presynaptic proteins are detected in the neocortex, hippocampus, striatum, thalamus, and cerebellum regions1,2. β-Synuclein has been shown to act as a negative regulator of α-synuclein aggregation both in vivo and in vitro1,2. Structure wise, the protein contains a highly conserved N-terminal domain which includes a repetitive amino acid motif, and a more divergent and highly acidic stretch at the C-terminal domain2,3.Studies have shown overexpressed mRNA levels of β-synuclein in Parkinson's disease suggesting that the protein has a valuable role in maintaining homeostasis in the disease pathology. In addition, studies have shown the action of β-synuclein as a neurodegeneration-inducing factor that can cause cell loss when expressed in rat brains1,2.β-Synuclein is also implicated with dementia involving Lewy bodies. To date, two mutations in the protein, V70M and P123H, have been identified in the sporadic and familial disease3.
Alternative names: Beta-Synuclein, beta-Synuclein, Synuclein beta, PNP 14, SNCB -
基因ID
- 113893
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NCBI登录号
- NM_001001502
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UniProt
- Q63754
抗原
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