SYNGAP1 抗体 (AA 1185-1199)
Quick Overview for SYNGAP1 抗体 (AA 1185-1199) (ABIN7043789)
抗原
See all SYNGAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1185-1199
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原理
- A Rabbit Polyclonal Antibody to SynGAP
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特异性
- C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-SynGAP Antibody (ABIN7043789, ABIN7045176 and ABIN7045177) is a highly selective antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SynGAP from human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KSMDESRLDRVKEYE, corresponding to amino acid residues 1185-1199 of rat SynGAP
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亚型
- IgG
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anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) (AA 1161-1343) antibody
SYNGAP1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) (C-Term) antibodySYNGAP1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) (AA 60-72) antibodyVerified SYNGAP1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) (AA 1169-1183) antibodyVerified SYNGAP1 适用: 人, 小鼠 WB, ELISA, IF, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) antibodySYNGAP1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:400
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说明
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Negative Control: (ABIN7237319)
Blocking Peptide: (ABIN7237319)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))
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别名
- SYNGAP1
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背景
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SynGAP1, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1, Neuronal RasGAP, p135 SynGAP,SynGAP1 is a major signaling protein that plays a pivotal role in regulating fundamental molecular changes in dendritic spine synaptic morphological and functional modifications.SynGAP1 functions as a downstream component of NMDA receptor-associated signaling and of AMPA receptor trafficking to excitatory postsynaptic membrane. SynGAP1 is mainly expressed in the hippocampus and cortex.SynGAP1 is a cytosolic protein without a signal peptide or any transmembrane domain. The N-terminal half of SYNGAP1 has a Ras-GAP domain, along with the region that is loosely homologous to Pleckstrin homology and a C2 domain which is potentially involved in binding Ca2+ and phospholipids. Interestingly, the alignment of GAP domain of SynGAP1 with other Ras-GAPs suggests that the amino acids in the GAP domain are crucial for interacting with Ras and for stimulating Ras-GTPase activity. The C-terminal half consists of a repeat of 10 histidines that may be involved in metal chelation, several potential serine and tyrosine phosphorylation sites and a T/SXV motif necessary for interaction with SAP102 and PSD-95.SynGAP1 has been implicated in the pathogenesis of intellectual disability. de novo out-of-frame deletions were identified in patients with intellectual disability presenting with microcephaly and generalized epilepsy while de novo microdeletions in chromosome region 6p21.3 were observed in patients with severe language impairment in addition to epilepsy. SynGAP1 may also be involved in the pathogenesis of schizophrenia through altered regulation of the NMDA receptor complex.
Alternative names: SynGAP, SynGAP1, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1, Neuronal RasGAP, p135 SynGAP -
基因ID
- 192117
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NCBI登录号
- NM_006772
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UniProt
- Q9QUH6
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途径
- Regulation of long-term Neuronal Synaptic Plasticity
抗原
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