SSTR5 抗体 (Extracellular)
Quick Overview for SSTR5 抗体 (Extracellular) (ABIN7043767)
抗原
See all SSTR5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-15, Extracellular
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原理
- A Polyclonal Antibody to Somatostatin Receptor Type 5
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 12,14 amino acid residues identical
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产品特性
- Anti-Somatostatin Receptor Type 5 (extracellular) Antibody is directed against an epitope of rat SSTR5. Anti-Somatostatin Receptor Type 5 (extracellular) Antibody (ABIN7043767 and ABIN7045267), can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize SSTR5 in human, mouse and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CEPLSLASTPSWNAS, corresponding to amino acid residues 2-15 of rat SSTR5
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亚型
- IgG
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anti-Somatostatin Receptor 5 (SSTR5) antibody
SSTR5 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Monoclonal unconjugated
anti-Somatostatin Receptor 5 (SSTR5) antibodySSTR5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Somatostatin Receptor 5 (SSTR5) (AA 300-350) antibodySSTR5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Somatostatin Receptor 5 (SSTR5) (AA 1-364) antibodySSTR5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Somatostatin Receptor 5 (SSTR5) (2nd Extracellular Domain) antibodySSTR5 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC
Negative Control: (ABIN7237251)
Blocking Peptide: (ABIN7237251)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SSTR5 (Somatostatin Receptor 5 (SSTR5))
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别名
- SSTR5
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背景
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SSTR5, SS5R, Smstr5, SST5,Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as almost every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28, that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. In target cells, SST induces a variety of physiological functions that include neuromodulation, cell secretion, cell proliferation and smooth muscle contractility.SST acts on its multiple cell targets via a family of six receptors that originate from five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell response via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation.In contrast to SSTR1-4 that bind SST-14 and SST-28 with similar affinity, SSTR5 has a much greater affinity to SST-28 over SST-14.SSTRs are widely expressed in both the brain and peripheral tissues but with receptor subtype variations between the different cell types.Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis, several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain.SSTR5 is expressed in a variety of tissues and cells, including pancreas, colonic mucosa, small intestine, heart, and vascular smooth muscle cells.SSTR5 has been shown to mediate growth inhibition and cell proliferation, and to play an important role in cancer growth regulation as one of the most potent inhibitory receptors.
Alternative names: Somatostatin Receptor Type 5, SSTR5, SS5R, Smstr5, SST5 -
基因ID
- 25354
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NCBI登录号
- NM_001053
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UniProt
- P30938
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途径
- Carbohydrate Homeostasis
抗原
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