SLC1A5 抗体 (C-Term, Intracellular)
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Quick Overview for SLC1A5 抗体 (C-Term, Intracellular) (ABIN7886778)
抗原
See all SLC1A5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 502-516, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to ASCT2 Transporter
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- Will not recognize ASCT2 from human samples.
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预测反应
- Rat - 14,15 amino acid residues identical
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产品特性
- Anti-ASCT2 (SLC1A5) Antibody (ABIN7043668, ABIN7044823 and ABIN7044824) is a highly selective antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry analysis. It has been designed to recognize SLC1A5 from mouse and rat samples. It will not recognize human ASCT2.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KMPSSEPELIQVKNE, corresponding to amino acid residues 502-516 of mouse SLC1A5
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亚型
- IgG
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anti-Solute Carrier Family 1 Member 5 (SLC1A5) antibody
SLC1A5 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 1 Member 5 (SLC1A5) (Internal Region) antibodySLC1A5 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 1 Member 5 (SLC1A5) (Middle Region) antibodySLC1A5 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, Pig, 绵羊, 豚鼠, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 1 Member 5 (SLC1A5) (AA 241-290) antibodySLC1A5 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, Pig, 绵羊, 猴, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 1 Member 5 (SLC1A5) (AA 1-100) antibodySLC1A5 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 1 Member 5 (SLC1A5) (2nd Extracellular Loop), (AA 202-217) antibody (FITC)SLC1A5 适用: 人 FACS, LCI 宿主: 兔 Polyclonal FITC
anti-Solute Carrier Family 1 Member 5 (SLC1A5) (2nd Extracellular Loop), (AA 202-217) antibody (PE)SLC1A5 适用: 人 FACS, LCI 宿主: 兔 Polyclonal PE
anti-Solute Carrier Family 1 Member 5 (SLC1A5) antibodySLC1A5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 1 Member 5 (SLC1A5) antibodySLC1A5 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236918)
Blocking Peptide: (ABIN7236918)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- SLC1A5 (Solute Carrier Family 1 Member 5 (SLC1A5))
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别名
- SLC1A5
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背景
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Synonyms: Alanine/serine/cysteine transporter 2, Neutral amino acid transporter B(0), ATB(0), ATBO, Sodium-dependent neutral amino acid transporter type 2, AAAT
Description: ASCT2 is an alanine-serine-cysteine amino acid transporter and solute linked carrier family 1 member A5 (SLC1A5). It functions as an essential high-affinity glutamine transporter. It also functions as a Na+-dependent transporter for alanine, serine and cysteine. The transport process is electroneutral which involves the Na+-coupled influx of glutamine to the Na+-coupled efflux of another substrate such as alanine, serine or cysteine. ASCT2 is expressed various peripheral tissues such as the lung and kidney1,2. ASCT2 has an important contribution to the homeostasis of amino acid metabolism within tumor cells3.ASCT2 seems to be up regulated in several cancerous tissues such as stomach, liver, kidney, breast, prostate, skin, colorectal, pancreatic, tongue and lung cancers. Studies have shown that ASCT2 is necessary for activating critical survival and cellular growth signaling cascades in cancer, which includes mTOR and ERK pathways. It has been shown that knockdown of ASCT2 in prostate cancer cell line xenograft models significantly inhibit tumor growth and metastasis in vivo. Thus, ASCT2 is a potential cancer therapeutic target1,2.
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基因ID
- 20514
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NCBI登录号
- NM_001145144
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UniProt
- P51912
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途径
- Dicarboxylic Acid Transport, Warburg Effect
抗原
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