SCN9A 抗体 (Intracellular)
Our Local Distributor
北京 101111
Quick Overview for SCN9A 抗体 (Intracellular) (ABIN7043647)
抗原
See all SCN9A 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- AA 446-460, Intracellular
-
原理
- A Rabbit Polyclonal Antibody to NaV1.7 (SCN9A) Channel
-
特异性
- Intracellular loop between domains I and II
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- human,mouse - 13,15 amino acid residues identical,Rabbit - 14
-
产品特性
- Anti-NaV1.7 (SCN9A) Antibody (ABIN7043647, ABIN7045229 and ABIN7045230) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize NaV1.7 from rat, human, and mouse samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)EFTSIGRSR IMGLSE, corresponding to amino acid residues 446-460 of rat NaV1.7
-
亚型
- IgG
-
-
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody
SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) unconjugated
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody (HRP)SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) HRP
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody (FITC)SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) FITC
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody (Biotin)SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) Biotin
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody (PE)SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) PE
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody (PerCP)SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) PerCP
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody (APC)SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) APC
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody (Atto 488)SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) Atto 488
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody (Atto 594)SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) Atto 594
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946) antibody (Atto 390)SCN9A 适用: 人 IHC, WB, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal N68-6 (Formerly S68-6) Atto 390
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
-
说明
-
Cited Application: IHC|ICC
Negative Control: (ABIN7236859)
Blocking Peptide: (ABIN7236859)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))
-
别名
- SCN9A
-
背景
-
Voltage-gated sodium channel type IX subunit alpha, PN1, NENA, NE, ETHA,Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability1. NaV channels are activated in response to depolarization and selectively allow the flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.94-5. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9)2-3.Mammalian sodium channels are heterotrimers composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas Na+ channels in adult skeletal muscle have only the β1 subunit6,8.NaV1.7 is predominantly expressed in dorsal root ganglions (DRG) of the peripheral nervous system. Dominant gain of function mutations in the NaV1.7 gene are associated with erythermalgia (a rare autosomal disease characterized by sporadic burning pain accompanied by redness and heat in the extremities).9-11 Loss of function mutations in NaV1.7 channels leads to complete ablation of pain perception in humans.11 These recent findings highlight the role of this NaV isoform and the subset of DRG neurons that express this channel in physiological pain sensation.
Alternative names: NaV1.7 (SCN9A), Voltage-gated sodium channel type IX subunit alpha, PN1, NENA, NE, ETHA -
基因ID
- 78956
-
NCBI登录号
- NM_002977
-
UniProt
- O08562
抗原
-
