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Serotonin Receptor 4 抗体 (2nd Extracellular Loop) (FITC)

The FITC-conjugated 兔多克隆 anti-Serotonin Receptor 4 antibody (ABIN7043625) specifically detects Serotonin Receptor 4 in FACS 和 LCI. The antibody is reactive with 大鼠 samples.

Cell surface detection of 5HT4 receptor in live intact human THP-1 monocytic leukemia cells: (black line) Cells. (Serotonin Receptor 4 抗体 (2nd Extracellular Loop) (FITC))

FACS

Cell surface detection of 5HT4 receptor in live intact mouse J774 macrophage cells: (black line) Cells. (Serotonin Receptor 4 抗体 (2nd Extracellular Loop) (FITC))

FACS

2 images

产品编号 ABIN7043625

发货至: 中国

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Quick Overview for Serotonin Receptor 4 抗体 (2nd Extracellular Loop) (FITC) (ABIN7043625)

抗原

See all Serotonin Receptor 4 (HTR4) 抗体

Serotonin Receptor 4 (HTR4)

适用

大鼠

宿主

兔

克隆类型

多克隆

标记

This Serotonin Receptor 4 antibody is conjugated to FITC

应用范围

Flow Cytometry (FACS), Live Cell Imaging (LCI)

Discover our top product HTR4 Primary Antibody

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2nd Extracellular Loop, AA 168-180

原理

A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 4 Conjugated to the Fluorescent Dye FITC

交叉反应

人, 小鼠, 大鼠

预测反应

Mouse - 12,13 amino acid residues identical, human - 11

产品特性

Anti-5HT4 Receptor (HTR4) (extracellular) Antibody (ABIN7043624, ABIN7045290 and ABIN7045291) is a highly specific antibody directed against an epitope of the rat Serotonin receptor 4. The antibody can be used in western blot, immunocytochemistry, and live cell imaging applications. It has been designed to recognize 5HT4 receptor from rat, mouse, and human samples. \nAnti-5HT4 Receptor (HTR4) (extracellular)-FITC Antibody (ABIN7043624, ABIN7045290 and ABIN7045291)-F) is directly conjugated to fluorescein isothiocyanate (FITC). The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.

纯化方法

Affinity purified on immobilized antigen.

免疫原

(C)DVIEKRKFNHNSN, corresponding to amino acid residues 168-180 of rat 5-Hydroxytryptamine receptor 4

亚型

IgG
anti-Serotonin Receptor 4 (HTR4) (AA 316-388) antibody
HTR4 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Serotonin Receptor 4 (HTR4) (Cytoplasmic Domain) antibody
HTR4 适用: 人, Cow, Pig, 犬, 马, 兔, 猴, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Serotonin Receptor 4 (HTR4) (C-Term) antibody
HTR4 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Serotonin Receptor 4 (HTR4) (2nd Extracellular Loop), (AA 168-180) antibody
KO Validated HTR4 适用: 大鼠 WB, FACS, LCI, IC 宿主: 兔 Polyclonal unconjugated

anti-Serotonin Receptor 4 (HTR4) (AA 21-120) antibody
HTR4 适用: 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Serotonin Receptor 4 (HTR4) (Middle Region) antibody
HTR4 适用: 人, 大鼠, 小鼠, Cow, Pig, 犬 WB 宿主: 兔 Polyclonal unconjugated

anti-Serotonin Receptor 4 (HTR4) (N-Term) antibody
HTR4 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Serotonin Receptor 4 (HTR4) (C-Term) antibody
HTR4 适用: 人, Cow, 犬, 马, 豚鼠, 兔, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Serotonin Receptor 4 (HTR4) (C-Term) antibody
HTR4 适用: 人, Pig, 马, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Serotonin Receptor 4 (HTR4) (AA 144-193) antibody
HTR4 适用: 人, 大鼠, Cow, 犬, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: The optimal concentration should be determined by the user
FC: 2.5-5 mg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user

说明

Negative Control: (ABIN7582044)
Blocking Peptide:

限制

仅限研究用
状态

Lyophilized

溶解方式

50 μL double distilled water (DDW).

浓度

1 mg/mL

缓冲液

PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
抗原

Serotonin Receptor 4 (HTR4)

别名

HTR4

背景

Synonyms: 5-Hydroxytryptamine receptor 4, Serotonin receptor 4
Description: 5-hydroxytryptamine receptor 4 (5-HT4 receptor) is a subclass among the large family of receptors mediating serotonin signaling at central and peripheral targets. 5-HT4 receptor activation plays a role in learning and memory, feeding control and stress response. 5-HT4 receptors are encoded by a complex gene which in humans, generates ten different splice variants1, 2.5-HT4 receptor is a member of the seven transmembrane spanning G-protein-coupled receptors (GPCRs) and couples via Gs to increase cAMP production. GPCRs share a similar topology, with seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs), the N-terminus is on the extracellular side of the membrane, and the C-terminus is cytoplasmic3.Within the central nervous system, these receptors are expressed in limbic structures including: hypothalamus, nucleus accumbens, prefrontal cortex, amygdala and hippocampus, where they contribute to emotional and cognitive functions4.Low levels of 5-HT4 receptors are associated with numerous neuropsychiatric disorders including Alzheimer's disease, Huntington's disease, feeding disorders and stress-related disorders such as anxiety and depression5.

基因ID

25324

NCBI登录号

NM_000870

UniProt

Q62758

途径

JAK/STAT Signaling, cAMP Metabolic Process, S100 Proteins