Serotonin Receptor 4 抗体 (2nd Extracellular Loop)
Our Local Distributor
北京 101111
Quick Overview for Serotonin Receptor 4 抗体 (2nd Extracellular Loop) (ABIN7043624)
抗原
See all Serotonin Receptor 4 (HTR4) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- 2nd Extracellular Loop, AA 168-180
-
原理
- A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 4
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse - 12,13 amino acid residues identical, human - 11
-
产品特性
- Anti-5HT4 Receptor (HTR4) (extracellular) Antibody (ABIN7043624, ABIN7045290 and ABIN7045291) is a highly specific antibody directed against an epitope of the rat Serotonin receptor 4. The antibody can be used in western blot, immunocytochemistry, and live cell imaging applications. It has been designed to recognize 5HT4 receptor from rat, mouse, and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)DVIEKRKFNHNSN, corresponding to amino acid residues 168-180 of rat 5-Hydroxytryptamine receptor 4
-
亚型
- IgG
-
-
anti-Serotonin Receptor 4 (HTR4) (AA 316-388) antibody
HTR4 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (Cytoplasmic Domain) antibodyHTR4 适用: 人, Cow, Pig, 犬, 马, 兔, 猴, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (C-Term) antibodyHTR4 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (AA 21-120) antibodyHTR4 适用: 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (Middle Region) antibodyHTR4 适用: 人, 大鼠, 小鼠, Cow, Pig, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (N-Term) antibodyHTR4 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (C-Term) antibodyHTR4 适用: 人, Cow, 犬, 马, 豚鼠, 兔, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (C-Term) antibodyHTR4 适用: 人, Pig, 马, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (AA 144-193) antibodyHTR4 适用: 人, 大鼠, Cow, 犬, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (AA 1-30), (N-Term) antibodyHTR4 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB32049 unconjugated
-
-
应用备注
-
WB: 1:200
FC: 2.5 mg per reaction
ICC: 1:100
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- Serotonin Receptor 4 (HTR4)
-
别名
- HTR4
-
背景
-
Synonyms: 5-Hydroxytryptamine receptor 4, Serotonin receptor 4
Description: 5-hydroxytryptamine receptor 4 (5-HT4 receptors) are a subclass among the large family of receptors mediating serotonin actions at central and peripheral targets. 5-HT4 receptor activation has been implicated in learning and memory, feeding control and stress response. 5-HT4 receptors are encoded by a complex gene which in humans, generates ten different splice variants1, 2.The 5-HT4 receptor, a member of the seven transmembrane spanning G-protein-coupled receptors (GPCRs), couples via Gs to increase cAMP production. GPCRs share a similar topology, with seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs), the N-terminus is on the extracellular side of the membrane, and the C-terminus is on the cytoplasmic side3.Within the central nervous system, these receptors are expressed in limbic structures including: hypothalamus, nucleus accumbens, prefrontal cortex, amygdala and hippocampus, where they contribute to emotional and cognitive functions4.Low levels of 5-HT4 receptors are associated with numerous neuropsychiatric disorders including Alzheimer's disease, Huntington's disease, feeding disorders and stress-related disorders such as anxiety and depression5.
-
基因ID
- 25324
-
NCBI登录号
- NM_000870
-
UniProt
- Q62758
-
途径
- JAK/STAT Signaling, cAMP Metabolic Process, S100 Proteins
抗原
-
