Serotonin Receptor 3A 抗体 (2nd Cytoplasmic Loop)
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Quick Overview for Serotonin Receptor 3A 抗体 (2nd Cytoplasmic Loop) (ABIN7043621)
抗原
See all Serotonin Receptor 3A (HTR3A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Cytoplasmic Loop, AA 342-355
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原理
- A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 3A
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,14 amino acid residues identical
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产品特性
- Anti-5HT3A Receptor (HTR3A) Antibody (ABIN7043621, ABIN7045283 and ABIN7045284) is a highly specific antibody directed against an epitope of rat Serotonin receptor 3A. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize 5-HT3A from mouse, human, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RPVPDWLRHLVLDR, corresponding to amino acid residues 342-355 of rat 5-Hydroxytryptamine receptor 3A
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亚型
- IgG
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anti-Serotonin Receptor 3A (HTR3A) (AA 24-157) antibody
HTR3A 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 3B11C10 unconjugated
anti-Serotonin Receptor 3A (HTR3A) (Internal Region) antibodyVerified HTR3A 适用: 人, 大鼠 ELISA, IHC, ICC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Serotonin Receptor 3A (HTR3A) (N-Term) antibodyHTR3A 适用: 人, 大鼠, 小鼠, 犬, Cow, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3A (HTR3A) (AA 31-130) antibodyHTR3A 适用: 人 ELISA, IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3A (HTR3A) (AA 24-241) antibodyHTR3A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3A (HTR3A) (N-Term) antibodyHTR3A 适用: 人, 大鼠, 小鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3A (HTR3A) (AA 21-36) antibodyHTR3A 适用: 人, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3A (HTR3A) (AA 322-455) antibodyHTR3A 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3A (HTR3A) (AA 301-400) antibodyHTR3A 适用: 大鼠, 小鼠 WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3A (HTR3A) (AA 301-350) antibodyHTR3A 适用: 人, 大鼠, 小鼠, 犬, 小鸡, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:400
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Serotonin Receptor 3A (HTR3A)
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别名
- HTR3A
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背景
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Synonyms: 5-Hydroxytryptamine receptor 3A, Serotonin receptor 3A, Serotonin-gated ion channel receptor 3A
Description: 5-Hydroxytryptamine receptor 3A (5-HT3A, HTR3A) belongs to the superfamily of ligand-gated ion channels. Serotonin receptors, other than the 5-HT3 subtype, belong to the superfamily of G-protein coupled receptors.The 5-HT3 receptor is formed by five subunits arranged around a pore forming unit. Receptors could be either monomeric, such as 5-HT3A or heteromeric entities like 5-HT3A/B. Indeed, the type of channel formed displays different pharmacological and electrophysiological characteristics1,2. To date, five 5-HT3 subunits have been identified and labeled 5-HT3A-E, which show variability in the N-terminus and in the transmembrane region2. 5-HT3A and 5-HT3B are the best characterized among the different types.In general, 5-HT3 receptors are located in the peripheral and central nervous system, in lymphocytes and intestinal enterochromaffine cells2. In presynaptic neurons, activation of these receptors leads to an increase in intracellular Ca2+ (by both influx and mobilization of intracellular stores), and modulates the release of a number of neurotransmitters and neuropeptides2. At the postsynaptic level, activation leads to membrane depolarization2,3. The 5-HT3A subunit is expressed in GABAergic and enkephalinergic neurons in the spinal dorsal horn thereby marking its possible antinociceptive effect4.5-HT3 receptors have become important targets for which to develop treatments for irritable bowel syndrome (IBS), side effects resulting from chemotherapeutic treatment, schizophrenia and bipolar disorder1,2.
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基因ID
- 79246
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NCBI登录号
- NM_000869
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UniProt
- P35563
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途径
- Synaptic Membrane
抗原
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