RTN4R 抗体 (Extracellular) (FITC)
Quick Overview for RTN4R 抗体 (Extracellular) (FITC) (ABIN7043602)
抗原
See all RTN4R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 366-381, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Nogo Receptor Conjugated to the Fluorescent Dye FITC
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特异性
- Extracellular
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - 15,16 amino acid residues identical
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产品特性
- Anti-Nogo Receptor (extracellular) Antibody (ABIN7043601, ABIN7044757 and ABIN7044758) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize NgR1 from human, mouse and rat samples. \nAnti-Nogo Receptor (extracellular)-FITC Antibody (ABIN7043601, ABIN7044757 and ABIN7044758)-F) is directly conjugated to fluorescein isothiocyanate (FITC). The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)GDSPPGNGSGPRHIND corresponding to amino acid residues 366-381 of the human Nogo receptor
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亚型
- IgG
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anti-Reticulon 4 Receptor (RTN4R) (AA 151-350) antibody
RTN4R 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 366-381), (Extracellular) antibodyRTN4R 适用: 人 WB, IHC, FACS, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) antibodyRTN4R 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 1-473) antibodyRTN4R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 244-473) antibodyRTN4R 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 1-473) antibodyRTN4R 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (Internal Region) antibodyVerified RTN4R 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) antibodyRTN4R 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: N/A
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说明
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Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7236730)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- RTN4R (Reticulon 4 Receptor (RTN4R))
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别名
- RTN4R
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背景
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NogoR, Nogo-R, NgR, NgR1, Nogo-66 receptor, Reticulon 4 receptor, RTN4R,Neurite outgrowth inhibitor receptor 1 (NgR1, Nogo Receptor) is a glycosylphosphatidylinositol (GPI) transmembrane protein expressed on the surface of axons in the CNS. Its key binding domain is an extracellular leucine-rich repeat domain that interacts with Myelin-associated inhibitory factors (MAIFs) composed of MAG, Neurite outgrowth inhibitor (Nogo)-A, and OMgp1,2.NgR1 binds to Neurite outgrowth inhibitor (Nogo) through a short hydrophilic loop between two hydrophobic domains. This binding activates intracellular molecular switches through the heteromerization with NgR1 co-receptors, p75NTR and LINGO-1.This process facilitates neurite outgrowth dynamics, it also governs the plasticity of the CNS at the axo-dendritic and axo-glial levels3.During CNS neurodegenerative disorders and in animal models of inflammatory demyelination, MAIFs, containing Nogo, accumulate and therefore there is an increased binding to their cognate receptor. This marks Nogo-NgR1 interaction as a potential target of new therapeutics for neurodegenerative diseases4.
Alternative names: Nogo Receptor, NogoR, Nogo-R, NgR, NgR1, Nogo-66 receptor, Reticulon 4 receptor, RTN4R -
基因ID
- 65078
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NCBI登录号
- NM_023004
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UniProt
- Q9BZR6
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途径
- Neurotrophin Signaling Pathway
抗原
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