RTN4R 抗体 (Extracellular)
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Quick Overview for RTN4R 抗体 (Extracellular) (ABIN7043601)
抗原
See all RTN4R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 366-381, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Nogo Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - 15,16 amino acid residues identical
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产品特性
- Anti-Nogo Receptor (extracellular) Antibody is directed against an extracellular epitope of the human Nogo receptor. Anti-Nogo Receptor (extracellular) Antibody (ABIN7043601, ABIN7044757 and ABIN7044758) can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize NgR from human, mouse and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)GDSPPGNGSGPRHIND corresponding to amino acid residues 366-381 of the human Nogo receptor
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亚型
- IgG
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anti-Reticulon 4 Receptor (RTN4R) (AA 151-350) antibody
RTN4R 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) antibodyRTN4R 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 1-473) antibodyRTN4R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 244-473) antibodyRTN4R 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) antibodyRTN4R 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB1005 unconjugated Recombinant Antibody
anti-Reticulon 4 Receptor (RTN4R) (AA 1-473) antibodyRTN4R 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (Internal Region) antibodyVerified RTN4R 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) antibodyRTN4R 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 366-381), (Extracellular) antibody (FITC)RTN4R 适用: 人 FACS 宿主: 兔 Polyclonal FITC
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7236730)
Blocking Peptide: (ABIN7236730)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- RTN4R (Reticulon 4 Receptor (RTN4R))
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别名
- RTN4R
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背景
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Synonyms: NogoR, Nogo-R, NgR, NgR1, Nogo-66 receptor, Reticulon 4 receptor, RTN4R
Description: The Nogo receptor is a leucine-rich repeat (LRR) containing protein with a glycosylphosphatidylinositol (GPI) anchored C-terminus. The receptor was identified on the basis of its ability to bind with high affinity to Nogo-A a member of the reticulon family expressed in the cell membrane of oligodendrocytes.1Nogo-A attracted attention when it was demonstrated that it is a myelin protein capable of inhibiting axonal growth following nerve injury.2,3 Other myelin proteins also identified as axonal growth inhibitors are the myelin-associated glycoprotein (MAG) a sialic-dependent immunoglobulin-like family member lectin (SIGLEC) and the oligodendrocyte myelin glycoprotein (OmgP) which is a GPI-anchored membrane protein. Remarkably, despite their structural diversity, all three axonal growth inhibitors bind to the Nogo receptor with high affinity.4,5Since the Nogo receptor is a GPI-anchored protein it was expected that it would require another protein component to transduce the Nogo-A binding information into the responding neurons interior. Indeed, it was shown that the neurotrophin receptor p75 (p75NTR) interacts with Nogo receptor and a third protein termed LINGO-1 to mediate axonal growth inhibition signaling.6,7
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基因ID
- 65078
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NCBI登录号
- NM_023004
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UniProt
- Q9BZR6
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途径
- Neurotrophin Signaling Pathway
抗原
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